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<正>作为参与能量转换、铁收集、氧运输和细胞内氧化代谢必需酶的催化辅助因子,细胞中适量的铜对生命活动是不可替代的[1]。然而,通过稳态机制可以确保细胞内的铜浓度维持在低水平,以防止细胞内有害游离铜的积累[2]。另一方面,铜固有的氧化还原特性使其对细胞既有益又有潜在毒性。Cu2+和Cu+是铜的两种氧化态,其中Cu+被认为是细胞质还原环境中的主要形式。其他必需金属,如铁的毒性机制已经明确,但铜诱导的细胞毒性机制仍旧是个谜团。
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基本信息:
DOI:
中图分类号:R730.2
引用信息:
[1]黄本林,付瑞,王宁等.铜死亡与肿瘤的关系研究进展[J].临床误诊误治,2022,35(11):112-116.
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